Staffan Strömblad: A Systems Microscopy research platform for analysis of system form and function in cell migration

Cell migration is a complex behavior that emerges at the cellular scale from interactions between innumerable individual actors at the molecular scale. A quantitative exploration of how this migratory "function" arises from the underlying organizational "form" of the cellular system remains to be achieved. We present a Systems Microscopy research platform that is designed to address this challenge by employing live cell fluorescence imaging, quantitative image analysis and automated statistical interrogation techniques. This platform generates highly dimensioned quantitative data defining cell migration system form and function on a time-resolved, per cell basis with all spatial scales mathematically integrated. We leverage both induced and natural heterogeneity across the derived multi-scale data to capture mathematical relationships within the cell migration system. Ultimately, we employ statistical analyses of causality to define features of system form, such as adhesion complex dynamics, that potently regulate cell migration function. We thus begin to elucidate fundamental linkages between cell migration system form and function.   

Presentationen kommer att ges av  John Lock och Mehrdad Jafari-Mamaghani.